|
Tuberculosis, Pulmonary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Zip2 mRNA and protein levels in peripheral blood mononuclear cells (PBMC) from PTB (n1=23) and healthy controls (n2=42) were detected by quantitative real-time PCR and western blot, respectively. mRNA expression levels of another four zinc transporters, Zip1, Zip6, Zip8 and ZnT1, were detected by quantitative real-time PCR.
|
23686108 |
2013 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Zinc and its transporter ZIP6 are key mediators of breast cancer cell survival under high glucose conditions.
|
28833062 |
2017 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Zinc and its transporter ZIP6 are key mediators of breast cancer cell survival under high glucose conditions.
|
28833062 |
2017 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Western blot showed the expression of LIV-1 was higher in 61% liver carcinoma tissues than that in normal liver tissues.
|
23437163 |
2013 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
We then estimate a gene association network from gene expression data taken from a breast cancer tumor study, showing that scale-free structure prior recovers hubs, including the previously unknown hub SLC39A6, which is a zinc transporter that has been implicated with the spread of breast cancer to the lymph nodes.
|
21079769 |
2010 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We then estimate a gene association network from gene expression data taken from a breast cancer tumor study, showing that scale-free structure prior recovers hubs, including the previously unknown hub SLC39A6, which is a zinc transporter that has been implicated with the spread of breast cancer to the lymph nodes.
|
21079769 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
We propose ZIP6 and ZIP7 are key functional orthologues in human and rodent β-cells and highlight these zinc importers as important targets for exploring associations between zinc status and normal physiology of β-cells and their decline in Type 2 Diabetes.
|
28893192 |
2017 |
|
Tumor Progression
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We investigated the function of SLC39A6 and ways in which this variant affects tumor progression by studying ESCC samples and cell lines.
|
28209530 |
2017 |
|
Secondary malignant neoplasm of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
We characterized the mechanism by which LIV-1 drives human prostate cancer EMT in an androgen-refractory prostate cancer cells (ARCaP) prostate cancer bone metastasis model.
|
22110740 |
2011 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
These results support the clinical evaluation of SGN-LIV1A as a novel therapeutic agent for patients with LIV-1-expressing cancer.
|
25253783 |
2014 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
These results support the clinical evaluation of SGN-LIV1A as a novel therapeutic agent for patients with LIV-1-expressing cancer.
|
25253783 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.340 |
Therapeutic
|
disease |
CTD_human |
These results suggest that SLC39A6 has an important role in the prognosis of ESCC and may be a potential therapeutic target.
|
23644492 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.340 |
Biomarker
|
disease |
BEFREE |
These results suggest that SLC39A6 has an important role in the prognosis of ESCC and may be a potential therapeutic target.
|
23644492 |
2013 |
|
Malignant tumor of cervix
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results of real-time PCR showed that LIV-1 mRNA was significantly higher in cervical cancer in situ than in normal tissues.
|
17825787 |
2007 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results of real-time PCR showed that LIV-1 mRNA was significantly higher in cervical cancer in situ than in normal tissues.
|
17825787 |
2007 |
|
cervical cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results of real-time PCR showed that LIV-1 mRNA was significantly higher in cervical cancer in situ than in normal tissues.
|
17825787 |
2007 |
|
Cholera
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The mRNA levels of LIV-1 and pS2, two estrogen-responsive genes, are increased by the agents, cholera toxin (CT) plus 3-isobutyl-l-methylxanthine (IBMX), which cause an increase in cAMP in MCF-7 human breast cancer cells.
|
9027326 |
1996 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Mammary Neoplasms
|
0.350 |
Biomarker
|
group |
CTD_human |
Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.
|
12839489 |
2003 |
|
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.
|
12839489 |
2003 |
|
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.
|
12839489 |
2003 |
|
Osteopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Stress-shielding-induced osteopenia was assessed as the UIV-1/LIV-1, apex/LIV-1, and LIV+1/LIV-1 HU ratios (× 100).
|
30783802 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Similarly, SLC39A6 protein was significantly overexpressed in Kazakh ethnic ESCC compared with that in NEE.
|
26444413 |
2015 |
|
Carcinoma breast stage IV
|
0.010 |
Biomarker
|
disease |
BEFREE |
SGN-LIV1A: a novel antibody-drug conjugate targeting LIV-1 for the treatment of metastatic breast cancer.
|
25253783 |
2014 |
|
Mammary Neoplasms
|
0.350 |
Biomarker
|
group |
LHGDN |
Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts.
|
17786585 |
2008 |